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Tuesday, March 30, 2010

Another reason for ending scientific and medical research using non-human subjects

According to a new scientific study which you can read about at http://www.nature.com/news/2010/100330/full/news.2010.158.html ,


"Published animal trials overestimate by about 30% the likelihood that a treatment works because negative results often go unpublished.This is a surprisingly strong bias, says the study's lead author, Malcolm Macleod, a neurologist at the Centre for Clinical Brain Sciences at the University of Edinburgh, UK."


"Macleod and his collaborators turned to a stroke database called the Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Stroke (CAMARADES). An international team established the database in 2004 in response to poor translation of animal findings to clinical trials. Macleod's team combed through 525 studies, which encompassed 1,359 experiments testing a total of 16 different stroke treatments."


"The team first estimated the magnitude of publication basis. A given treatment would be expected to result in a balanced range of effect sizes, but they found that the literature included many reports of a large effect, but few reports of a small effect. The team then calculated the number of missing studies and came up with an estimate of the 'true' effect of the treatment. In addition to the large overestimate of treatment's efficacy, Macleod and his team found that as many as 16% of experiments remain unpublished."


" A little more than a third of highly cited animal research is reproduced later in human trials2, and although about 500 treatments have been reported as effective in animal models of stroke, only aspirin and early thrombolysis with tissue plasminogen activator work in humans3. The lack of negative results in the literature may explain why so few drugs tested in animals are effective in humans.Not reporting the negative results of animal trials is unethical says Macleod, because it squanders animals and leads to premature human trials. "If the research is not published, it doesn't contribute to our knowledge of human disease," he says."


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If only one third of all animal research is reproduced later in human trials, this obviously means that in 2/3's of the time experimental animals have been used and abused needlessly!    If science and medicine was exclusively using humans as test subjects in their studies and research and  it was revealed that only one third of the time this research was being reproduced in the general population,there would be a public outcry and scientists would be prevented from using human subjects in their testing! This new research clearly indicates that  some aspects of science, ,medicine and medical researche are out of control,  are misguided, and are amoral or valueless! 


Clearly these people knew that if they reported negative results, their research 
might come under scrutiny and their use of non-human life forms would be seriously opposed by more members of the general population.Not only that, their research funding might be cut off or severely reduced, but the  companies  and institutions they are working for would come under fire. If  these scientists are deliberately reporting an  overestimate of a treatment's efficacy, then we have to ask ourselves.....Why this is so, and why they are permitted to engage in such damgerous behavior when both human and non-human lives are at stake!!!










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Thoughts worth thinking about

"Our subconscious minds have no sense of humor, play no jokes and cannot tell the difference between reality and an imagined thought or image. What we continually think about eventually will manifest in our lives."-Sidney Madwed



Laws alone can not secure freedom of expression; in order that every woman and man present their views without penalty, there must be spirit of tolerance in the entire population.- Albert Einstein Too often we underestimate the power of a touch, a smile, a kind word, a listening ear, an honest compliment, or the smallest act of caring, all of which have the potential to turn a life around. - Leo Buscaglia



A person's true wealth is the good he or she does in the world. - Mohammed



Our task must be to free ourselves... by widening our circle of compassion to embrace all living creatures and the whole of nature and its beauty. -Albert Einstein



The best way to find yourself, is to lose yourself in the service of others. - Ghandi



The unselfish effort to bring cheer to others will be the beginning of a happier life for ourselves. - Helen Keller



Aim for success, not perfection. Never give up your right to be wrong, because then you will lose the ability to learn new things and move forward with your life. Remember that fear always lurks behind perfectionism. Confronting your fears and allowing yourself the right to be human can, paradoxically, make yourself a happier and more productive person. - Dr. David M. Burns



Life is as dear to a mute creature as it is to man. Just as one wants happiness and fears pain, just as one wants to live and not die, so do other creatures. -His Holiness The Dalai Lama



Mankind's true moral test, its fundamental test (which lies deeply buried from view), consists of its attitude towards those who are at its mercy: animals. And in this respect mankind has suffered a fundamental debacle, a debacle so fundamental that all others stem from it. -



Milan Kundera, The Unbearable Lightness of Being



The worst sin towards our fellow creatures is not to hate them, but to be indifferent to them. That's the essence of inhumanity. -George Bernard Shaw

Ego's trick is to make us lose sight of our interdependence. That kind of ego-thought gives us a perfect justification to look out only for ourselves. But that is far from the truth. In reality we all depend on each other and we have to help each other. The husband has to help his wife, the wife has to help the husband, the mother has to help her children, and the children are supposed to help the parents too, whether they want to or not.-Gehlek Rinpoche Source: "The Best Buddhist Writing 2005 pg. 165

The hostile attitude of conquering nature ignores the basic interdependence of all things and events---that the world beyond the skin is actually an extension of our own bodies---and will end in destroying the very environment from which we emerge and upon which our whole life depends.