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Tuesday, April 14, 2009

Old drugs used in new ways

Recent animal studies have shown that clioquinol - an 80-year old drug once used to treat gastrointestinal disorders can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders. Researchers at McGill University have discovered a dramatic possible new answer: According to Dr. Siegfried Hekimi and colleagues at McGill's Department of Biology, clioquinol acts directly on a protein called CLK-1, often informally called "clock-1," and might slow down the aging process. The advance online edition of their study was published in Oct. 2008 in the Journal of Biological Chemistry. "Clioquinol is a very powerful inhibitor of clock-1," explained Hekimi, McGill's Strathcona Chair of Zoology and Robert Archibald & Catherine Louise Campbell Chair in Developmental Biology. "Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging." To read the entire article go to:http://www.medicalnewstoday.com/articles/134583.php

Scientific research must be allowed to continue and be funded. According to a recent article published online:

"The Canadian Federal Government has recently caused "a funding crunch, (within the field of scientific research in Canada) exacerbated by cuts in the January budget, which has left many senior researchers across the county scrambling to find the money to continue their experiments.Many scientists fear 10 years of gains will be wiped out by a government that doesn't understand the importance of basic, curiosity-driven research, which history shows leads to the big discoveries. They worry Canada's best will decamp for the United States, where President Barack Obama has put $10-billion (U.S) into medical research as part of his plan to stimulate economic growth."
(source:http://www.theglobeandmail.com/servlet/story/RTGAM.20090317.
wgoodyear16/BNStory/National/home)


And now the new Liberal leader of Canada made news today by stating that if his party is elected as the next Governing party of Canada, he will institute severe spending cuts to our population and its institutions. This at a time when funding to science and scientific research should be increased, and not cut back futher. I hope that someone in the Federal Government of Canada will start to listen to Canadian scientists.

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Thoughts worth thinking about

"Our subconscious minds have no sense of humor, play no jokes and cannot tell the difference between reality and an imagined thought or image. What we continually think about eventually will manifest in our lives."-Sidney Madwed



Laws alone can not secure freedom of expression; in order that every woman and man present their views without penalty, there must be spirit of tolerance in the entire population.- Albert Einstein Too often we underestimate the power of a touch, a smile, a kind word, a listening ear, an honest compliment, or the smallest act of caring, all of which have the potential to turn a life around. - Leo Buscaglia



A person's true wealth is the good he or she does in the world. - Mohammed



Our task must be to free ourselves... by widening our circle of compassion to embrace all living creatures and the whole of nature and its beauty. -Albert Einstein



The best way to find yourself, is to lose yourself in the service of others. - Ghandi



The unselfish effort to bring cheer to others will be the beginning of a happier life for ourselves. - Helen Keller



Aim for success, not perfection. Never give up your right to be wrong, because then you will lose the ability to learn new things and move forward with your life. Remember that fear always lurks behind perfectionism. Confronting your fears and allowing yourself the right to be human can, paradoxically, make yourself a happier and more productive person. - Dr. David M. Burns



Life is as dear to a mute creature as it is to man. Just as one wants happiness and fears pain, just as one wants to live and not die, so do other creatures. -His Holiness The Dalai Lama



Mankind's true moral test, its fundamental test (which lies deeply buried from view), consists of its attitude towards those who are at its mercy: animals. And in this respect mankind has suffered a fundamental debacle, a debacle so fundamental that all others stem from it. -



Milan Kundera, The Unbearable Lightness of Being



The worst sin towards our fellow creatures is not to hate them, but to be indifferent to them. That's the essence of inhumanity. -George Bernard Shaw

Ego's trick is to make us lose sight of our interdependence. That kind of ego-thought gives us a perfect justification to look out only for ourselves. But that is far from the truth. In reality we all depend on each other and we have to help each other. The husband has to help his wife, the wife has to help the husband, the mother has to help her children, and the children are supposed to help the parents too, whether they want to or not.-Gehlek Rinpoche Source: "The Best Buddhist Writing 2005 pg. 165

The hostile attitude of conquering nature ignores the basic interdependence of all things and events---that the world beyond the skin is actually an extension of our own bodies---and will end in destroying the very environment from which we emerge and upon which our whole life depends.